Nootropics

14 cognitive enhancement compounds

Peptide Nootropics

A curated collection of research peptides studied for cognitive enhancement — from anxiety and mood support to memory formation, neuroprotection, and sleep quality. Most are administered intranasally or by subcutaneous injection. Click any compound to view its full profile, mechanism, and calculator presets.

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— well-researched, beginner-friendly
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Selank

TP-7

A synthetic heptapeptide analogue of tuftsin with anxiolytic, nootropic, and immune-modulating properties developed in Russia.

moderateBeginner
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Semax

ACTH 4-7 Pro8-Gly9-Pro10

A synthetic heptapeptide based on ACTH fragment with potent nootropic, neuroprotective, and stroke-recovery properties developed in Russia.

moderateBeginner
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DSIP

Delta Sleep-Inducing Peptide

A naturally occurring neuropeptide that regulates sleep-wake cycles, stress response, and has shown longevity-associated effects in animal research.

lowBeginner
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Noopept

GVS-111

A synthetic dipeptide-derived nootropic with potent NGF/BDNF-stimulating and memory-enhancing properties, widely used in Russia and research settings as an approved cognitive drug.

moderateBeginner
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Dihexa

PNB-0408

An extremely potent nootropic peptide (10 million times more potent than BDNF) that enhances synaptogenesis, with promising research in Alzheimer's models.

low
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Short neuroprotective tripeptide that crosses the blood-brain barrier and supports cognitive longevity.

preclinical
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P21 Peptide

CNTF-derived peptide

Short peptide from CNTF that stimulates neurogenesis and enhances brain-derived neurotrophic factor (BDNF) production.

preclinical
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PE-22-28

Spadin fragment

Synthetic octapeptide fragment of spadin that blocks TREK-1 potassium channels, producing rapid antidepressant and cognitive effects in preclinical models.

preclinical
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An acetylated derivative of Semax with enhanced potency and potentially more consistent activity compared to the parent compound, studied for cognitive enhancement and neuroprotection.

experimental
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An acetylated derivative of Selank with enhanced stability and potentially greater anxiolytic and nootropic activity compared to the parent compound.

experimental
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Cortagen

Ala-Glu-Asp-Pro

A synthetic tetrapeptide bioregulator derived from lung tissue, developed in the Russian peptide bioregulator program, studied for lung tissue regeneration, anti-inflammatory properties, and anti-aging effects in the bronchopulmonary system.

experimental
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NAP Peptide

NAPVSIPQ

An 8-amino acid peptide fragment derived from the ADNP (Activity-Dependent Neuroprotective Protein) gene, studied for neuroprotection, cognitive support, and potential applications in Alzheimer's disease and autism spectrum disorder.

preclinical
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DNSP-11

Dopaminergic Neuroprotective and Survival Peptide-11

An 11-amino acid synthetic peptide derived from the pro-peptide domain of GDNF, studied for dopaminergic neuroprotection, mood baseline restoration, mitochondrial support, and neurorestorative effects in Parkinson's-related models.

preclinical
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FGL Peptide

NCAM-FGL

A 15-amino acid peptide derived from the fibronectin type III (F3) module of neural cell adhesion molecule (NCAM), studied for synaptic plasticity enhancement, neuroprotection, cognitive improvement, and anti-inflammatory effects in preclinical models.

preclinical