Semax
ACTH 4-7 Pro8-Gly9-Pro10 · Met-Glu-His-Phe-Pro-Gly-Pro
A synthetic heptapeptide based on ACTH fragment with potent nootropic, neuroprotective, and stroke-recovery properties developed in Russia.
Half-Life
~2-3 minutes (plasma), longer CNS activity
MW
887.1 Da
Amino Acids
7 AA
Evidence
Moderate Evidence
Regulatory Status
Approved medication in Russia for neurological indications. Research compound elsewhere.
In Plain English
A nasal spray nootropic that boosts BDNF — the brain's fertilizer for neuron growth and connections. Based on a fragment of the stress hormone ACTH. Widely used in Russia for stroke recovery, focus, and brain protection.
Overview
Semax is a synthetic analogue of the ACTH 4-10 fragment developed at the Institute of Molecular Genetics, Moscow. It is approved in Russia for cognitive enhancement, stroke recovery, and other neurological applications. It is one of the most well-studied nootropic peptides with a track record of medical use.
Common Formats
- Nasal spray (most common)
- Injectable
Storage Notes
Refrigerate at 4°C. Do not freeze nasal spray.
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Related Compounds
Selank
A synthetic heptapeptide analogue of tuftsin with anxiolytic, nootropic, and immune-modulating properties developed in Russia.
Dihexa
An extremely potent nootropic peptide (10 million times more potent than BDNF) that enhances synaptogenesis, with promising research in Alzheimer's models.
DSIP
A naturally occurring neuropeptide that regulates sleep-wake cycles, stress response, and has shown longevity-associated effects in animal research.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.