FGL Peptide
NCAM-FGL · FGL · Neural Cell Adhesion Molecule FGL fragment
A 15-amino acid peptide derived from the fibronectin type III (F3) module of neural cell adhesion molecule (NCAM), studied for synaptic plasticity enhancement, neuroprotection, cognitive improvement, and anti-inflammatory effects in preclinical models.
Half-Life
Short in plasma (~30-60 minutes). Neurotrophic receptor signaling effects may persist for hours.
MW
~1.6 kDa (15-residue peptide, sequence: EVYVVAENQQGKSKA)
Amino Acids
15 AA
Evidence
Preclinical
Regulatory Status
Research compound only. No approved human applications. Studied in academic neuroscience and preclinical research settings.
In Plain English
A small peptide that mimics part of the brain's synaptic glue (NCAM) to directly activate the growth factor receptors that strengthen memory connections. FGL essentially tells neurons to form stronger, longer-lasting synaptic connections — the cellular basis of learning and memory. It also has notable anti-inflammatory effects in the brain. Studied mainly for age-related cognitive decline and neuroprotection.
Overview
FGL (named for its Phe-Gly-Leu partial sequence feature) is a synthetic peptide corresponding to residues from the second fibronectin type III (FNIII) module of NCAM (Neural Cell Adhesion Molecule). NCAM plays a fundamental role in synaptic plasticity, learning, and memory, and the FGL peptide was designed to mimic the region of NCAM that binds to the fibroblast growth factor receptor (FGFR). By activating FGFR signaling without requiring the full NCAM protein, FGL reproduces key downstream neurotrophic and plasticity-enhancing effects of NCAM. Preclinical research has demonstrated that FGL enhances LTP (long-term potentiation), improves spatial learning and memory in aged rodent models, reduces neuroinflammation, and provides neuroprotection against excitotoxic and age-related neuronal injury. It has been studied in the context of age-related cognitive decline, traumatic brain injury, and neurodegenerative disease prevention.
Common Formats
- Lyophilized powder (injectable research preparation)
- Intranasal formulation (research)
Storage Notes
Store lyophilized at -20°C. Reconstituted peptide solution: keep at 4°C and use within 3-5 days. Protect from light.
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