Noopept
GVS-111 · Omberacetam · N-phenylacetyl-L-prolylglycine ethyl ester
A synthetic dipeptide-derived nootropic with potent NGF/BDNF-stimulating and memory-enhancing properties, widely used in Russia and research settings as an approved cognitive drug.
Half-Life
~15-30 minutes (parent compound). Active metabolite cycloprolylglycine has longer CNS effects.
MW
318.37 Da
Amino Acids
2 AA
Evidence
Moderate Evidence
Regulatory Status
Approved prescription drug in Russia (brand: Noopept) for cognitive impairment. Research/unscheduled compound in US/EU. Not FDA approved.
In Plain English
A Russian-developed cognitive enhancer related to piracetam but much more potent. It works by boosting NGF and BDNF — the brain's own growth and repair hormones — while also enhancing the main memory-forming receptors (AMPA/NMDA). One of the most accessible and widely used research nootropics, and actually an approved drug in Russia.
Overview
Noopept (GVS-111, omberacetam) is a synthetic dipeptide derivative developed in Russia in the 1990s as a highly potent analog of piracetam. Structurally it is N-phenylacetyl-L-prolylglycine ethyl ester — a dipeptide-derived compound that crosses the blood-brain barrier and is metabolized to cycloprolylglycine, an endogenous neuropeptide. It has been approved as a nootropic prescription drug in Russia under the brand name Noopept for cognitive impairment. Noopept stimulates NGF and BDNF gene expression, potentiates AMPA and NMDA glutamate receptors, and provides neuroprotection. It is widely used as a cognitive enhancer in research settings and is one of the most studied and accessible research nootropics.
Common Formats
- Oral tablets/capsules (most common)
- Sublingual powder
- Nasal spray (research)
- Injectable (research, less common)
Storage Notes
Store in cool, dry place. Room temperature stable. Protect from moisture and light. Long shelf life.
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Research Sources
(1 vendor)For research use only. No affiliation or endorsement implied.
Related Compounds
Semax
A synthetic heptapeptide based on ACTH fragment with potent nootropic, neuroprotective, and stroke-recovery properties developed in Russia.
Selank
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Dihexa
An extremely potent nootropic peptide (10 million times more potent than BDNF) that enhances synaptogenesis, with promising research in Alzheimer's models.
P21 Peptide
Short peptide from CNTF that stimulates neurogenesis and enhances brain-derived neurotrophic factor (BDNF) production.
N-Acetyl Semax
An acetylated derivative of Semax with enhanced potency and potentially more consistent activity compared to the parent compound, studied for cognitive enhancement and neuroprotection.
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