P21 Peptide
CNTF-derived peptide · P21
Short peptide from CNTF that stimulates neurogenesis and enhances brain-derived neurotrophic factor (BDNF) production.
Half-Life
~1–3 hours (estimated)
MW
N/A
Amino Acids
N/A
Evidence
Preclinical
Regulatory Status
Research compound
In Plain English
Stimulates the brain to grow new neurons and form new connections by boosting BDNF. Derived from CNTF but without its inflammatory side effects. Research focused on Down syndrome cognition — preliminary results suggest memory benefits.
Overview
P21 is a small peptide derived from ciliary neurotrophic factor (CNTF) that maintains neurotrophic benefits while avoiding the inflammatory side effects of full CNTF. It crosses the blood-brain barrier and increases BDNF levels, promoting neurogenesis particularly in the hippocampus. Research suggests benefits for learning, memory, and potentially treatment of neurodegenerative conditions. Studied for effects on trisomy 21 (Down syndrome) cognition, hence the name.
Common Formats
- Injectable (subcutaneous)
- Intranasal
Storage Notes
Freeze at -20°C. Limited stability data at room temperature.
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Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.