NAP Peptide
NAPVSIPQ · Davunetide · AL-108
An 8-amino acid peptide fragment derived from the ADNP (Activity-Dependent Neuroprotective Protein) gene, studied for neuroprotection, cognitive support, and potential applications in Alzheimer's disease and autism spectrum disorder.
Half-Life
~2–4 hours (IV/intranasal); brain tissue distribution appears sustained beyond plasma half-life
MW
854.95 Da
Amino Acids
8 AA
Evidence
Preclinical
Regulatory Status
Research compound. Davunetide completed Phase 2 trials for Alzheimer's disease (results mixed) and Phase 2/3 for progressive supranuclear palsy (missed primary endpoint). Not FDA-approved.
In Plain English
A tiny 8-amino acid piece of a larger brain-development protein that seems to protect neurons from the damage seen in Alzheimer's disease and other neurodegenerative conditions. It's remarkable because it works at almost homeopathic concentrations — far smaller doses than most peptides — suggesting it acts more like a key in a very specific lock rather than a broad chemical signal.
Overview
NAP (NAPVSIPQ) is a short peptide derived from the larger ADNP protein — a master regulator of neural differentiation responsible for activating hundreds of genes during brain development. ADNP haploinsufficiency causes a rare neurodevelopmental syndrome (ADNP syndrome/Helsmoortel-Van der Aa syndrome). The NAP fragment retains potent neuroprotective activity at femtomolar-picomolar concentrations, far below what is needed for typical peptide activity. It has been developed as davunetide (AL-108, intranasal) and AL-208 (IV) for clinical trials in Alzheimer's disease, schizophrenia, and progressive supranuclear palsy.
Common Formats
- Lyophilized powder (injectable)
- Intranasal solution (davunetide format)
Storage Notes
Lyophilized: -20°C long term. Reconstituted in sterile saline: use promptly; refrigerate up to 1 week. Intranasal solutions per specific formulation guidance.
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Related Compounds
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Selank
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Dihexa
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