DNSP-11
Dopaminergic Neuroprotective and Survival Peptide-11 · DNSP11 · pro-GDNF derived peptide
An 11-amino acid synthetic peptide derived from the pro-peptide domain of GDNF, studied for dopaminergic neuroprotection, mood baseline restoration, mitochondrial support, and neurorestorative effects in Parkinson's-related models.
Half-Life
Short (estimated minutes to 1-2 hours in vivo). CNS effects may persist beyond plasma half-life due to sustained receptor activation.
MW
~1.3 kDa (11-residue peptide)
Amino Acids
11 AA
Evidence
Preclinical
Regulatory Status
Research compound only. No human clinical trials. Strictly preclinical stage.
In Plain English
A small peptide fragment derived from GDNF — the brain's "dopamine neuron fertilizer." DNSP-11 is designed to be small enough to get into the brain and protect dopamine-producing neurons, support mitochondrial health, and help normalize mood baseline. Studied mainly in Parkinson's disease research models, it's explored by advanced nootropic researchers for its neuroprotective and mood-stabilizing potential.
Overview
DNSP-11 (Dopaminergic Neuroprotective and Survival Peptide-11) is a synthetic 11-residue peptide corresponding to a segment of the pro-domain of Glial Cell Line-Derived Neurotrophic Factor (GDNF). While GDNF itself does not readily cross the blood-brain barrier (due to its large size), DNSP-11 was designed as a small, BBB-penetrant fragment that retains key neuroprotective actions on dopaminergic neurons. It has been studied primarily in the context of Parkinson's disease research, with research showing it can rescue dopamine neurons, restore mood baseline, support mitochondrial function, and promote neurorestorative outcomes in rodent models. It is discussed in advanced nootropic and peptide communities for its dual mood-baseline and neuroprotective profile.
Common Formats
- Lyophilized powder (subcutaneous or intranasal research preparation)
Storage Notes
Store lyophilized at -20°C. Reconstituted solution: refrigerate at 4°C and use within 3-5 days. Avoid repeated freeze-thaw cycles.
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Related Compounds
Semax
A synthetic heptapeptide based on ACTH fragment with potent nootropic, neuroprotective, and stroke-recovery properties developed in Russia.
N-Acetyl Semax
An acetylated derivative of Semax with enhanced potency and potentially more consistent activity compared to the parent compound, studied for cognitive enhancement and neuroprotection.
Pinealon
Short neuroprotective tripeptide that crosses the blood-brain barrier and supports cognitive longevity.
P21 Peptide
Short peptide from CNTF that stimulates neurogenesis and enhances brain-derived neurotrophic factor (BDNF) production.
Noopept
A synthetic dipeptide-derived nootropic with potent NGF/BDNF-stimulating and memory-enhancing properties, widely used in Russia and research settings as an approved cognitive drug.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.