Synthetic octapeptide fragment of spadin that blocks TREK-1 potassium channels, producing rapid antidepressant and cognitive effects in preclinical models.
Half-Life
~1–2 hours (estimated, short due to peptidase degradation)
MW
950.1 Da
Amino Acids
8 AA
Evidence
Preclinical
Regulatory Status
Research compound. No clinical trials or regulatory approval.
In Plain English
A short peptide that blocks a brain potassium channel (TREK-1) linked to depression and poor cognition. In animal studies it produces fast antidepressant effects — within hours rather than the weeks needed for SSRIs. Still in preclinical stages with no human data.
Overview
PE-22-28 is a synthetic 8-amino acid C-terminal fragment of spadin, itself a fragment of the natriuretic peptide proBNP. It selectively blocks TREK-1 (TWIK-related potassium channel 1), a two-pore domain potassium channel linked to depression, stress, and cognitive function. In rodent models, PE-22-28 produces rapid antidepressant-like effects comparable to or faster than conventional antidepressants, with onset within hours rather than weeks. It has also been studied for effects on hippocampal neurogenesis and memory.
Common Formats
- Injectable (subcutaneous)
- Intranasal
Storage Notes
Store at -20°C lyophilized. Reconstituted solution stable up to 2 weeks refrigerated. Sensitive to repeated freeze-thaw cycles.
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Research Sources
(3 vendors)For research use only. No affiliation or endorsement implied.
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