MOTS-c (Analog)
MOTS-c synthetic · Mitochondrial peptide analog
Synthetic analogs of the mitochondria-derived MOTS-c with enhanced stability and metabolic effects beyond the native peptide.
Half-Life
~2–6 hours (improved from native ~30 minutes)
MW
N/A
Amino Acids
N/A
Evidence
Preclinical
Regulatory Status
Research compound
In Plain English
An improved version of the MOTS-c mitochondrial peptide with modifications that make it last much longer in the body. Same metabolic benefits as native MOTS-c — better insulin sensitivity, mitochondrial function — with less frequent dosing needed.
Overview
MOTS-c analogs are modified versions of the naturally occurring mitochondria-encoded peptide MOTS-c with improved pharmacokinetic properties (resistance to degradation, extended half-life). The native MOTS-c (already in this database) has limited stability; analogs substitute D-amino acids or add chemical modifications to extend activity. Research shows enhanced exercise mimetics properties, insulin sensitization, and mitohormesis compared to native MOTS-c.
Common Formats
- Injectable (subcutaneous)
Storage Notes
Freeze at -20°C. More stable than native MOTS-c in solution.
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Related Compounds
MOTS-c
A mitochondrial-derived peptide that regulates metabolic homeostasis, glucose uptake, and has shown remarkable longevity effects in animal studies.
SS-31
A cardiolipin-targeted mitochondria-protective peptide showing remarkable results in heart failure, AMD, and mitochondrial disease research.
Humanin
A mitochondria-derived peptide encoded in the 16S rRNA region with remarkable cytoprotective, anti-apoptotic, and longevity-associated properties.
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