Humanin
HN · Mitochondria-derived peptide
A mitochondria-derived peptide encoded in the 16S rRNA region with remarkable cytoprotective, anti-apoptotic, and longevity-associated properties.
Half-Life
Not fully characterized
MW
2397.7 Da
Amino Acids
21 AA
Evidence
Low Evidence
Regulatory Status
Research use only.
In Plain English
A tiny peptide your mitochondria produce as a "keep us alive" signal. Levels drop sharply with age. Protects neurons, heart cells, and metabolic tissues from death — offspring of centenarians have notably higher levels.
Overview
Humanin is a 21-amino acid peptide encoded within the mitochondrial 16S rRNA. Like MOTS-c, it is a mitochondrial-derived peptide (MDP). It circulates as a hormone-like molecule and declines with aging. Studies show cytoprotective, anti-apoptotic, and potentially lifespan-extending effects.
Common Formats
- Lyophilized powder (injectable)
Storage Notes
-20°C to -80°C.
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Related Compounds
MOTS-c
A mitochondrial-derived peptide that regulates metabolic homeostasis, glucose uptake, and has shown remarkable longevity effects in animal studies.
Epitalon
A synthetic tetrapeptide based on Epithalamin with telomerase activation and antioxidant properties showing remarkable longevity effects in multiple animal species.
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