MOTS-c
Mitochondrial ORF of the 12S rRNA Type-C
A mitochondrial-derived peptide that regulates metabolic homeostasis, glucose uptake, and has shown remarkable longevity effects in animal studies.
Half-Life
Not well characterized
MW
2174.5 Da
Amino Acids
16 AA
Evidence
Low Evidence
Regulatory Status
Research use only. Early human trials beginning.
In Plain English
A remarkable peptide your own mitochondria encode and release as a metabolic distress signal. It travels to the cell nucleus and activates the same energy-sensing pathways triggered by exercise and caloric restriction.
Overview
MOTS-c is encoded within the mitochondrial genome (12S rRNA gene), making it unique among peptides. It regulates metabolic function by activating AMPK, improving insulin sensitivity, and has demonstrated anti-aging effects in studies. Its expression declines with age.
Common Formats
- Lyophilized powder (injectable)
Storage Notes
-20°C to -80°C. Sensitive to freeze-thaw cycles.
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Related Compounds
Epitalon
A synthetic tetrapeptide based on Epithalamin with telomerase activation and antioxidant properties showing remarkable longevity effects in multiple animal species.
Humanin
A mitochondria-derived peptide encoded in the 16S rRNA region with remarkable cytoprotective, anti-apoptotic, and longevity-associated properties.
GHK-Cu
A naturally occurring copper complex peptide with potent wound healing, anti-aging, and regenerative properties studied extensively for skin and tissue applications.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.