MK-677
Ibutamoren · Ibutamoren Mesylate · L-163,191
An orally active, non-peptide GH secretagogue that produces sustained GH and IGF-1 elevation, suitable for daily oral administration.
Half-Life
~24 hours
MW
624.77 Da
Amino Acids
N/A
Evidence
High Evidence
Regulatory Status
Research compound. Multiple Phase II human clinical trials completed. Not FDA-approved.
In Plain English
A pill that mimics ghrelin to significantly raise both growth hormone and IGF-1 levels. The only orally active GH secretagogue in widespread research use — convenient, but trade-offs include water retention and increased appetite.
Overview
MK-677 is a non-peptide orally active GH secretagogue that mimics ghrelin. Unlike peptide GH secretagogues requiring injection, MK-677 can be taken orally. It produces sustained (24h) elevation of GH and IGF-1 levels. Human clinical trials have demonstrated its efficacy.
Common Formats
- Oral capsules/tablets
- Solution
Storage Notes
Room temperature, away from moisture and light.
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Related Compounds
Ipamorelin
A highly selective GH secretagogue and ghrelin receptor agonist known for clean GH release without significant cortisol or prolactin stimulation.
CJC-1295
A long-acting GHRH analogue with a Drug Affinity Complex that extends its half-life dramatically, allowing weekly dosing for sustained GH elevation.
IGF-1 LR3
A potent long-acting variant of IGF-1 with a 13-amino acid extension and substitution that dramatically extends its half-life and prevents protein binding.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.