Triptorelin
Decapeptyl · Diphereline · Trelstar
A synthetic decapeptide GnRH agonist used clinically for prostate cancer, endometriosis, precocious puberty, and researched for HPTA restoration after anabolic steroid use.
Half-Life
~3 hours (subcutaneous/IM, non-depot). Depot formulations release over weeks to months.
MW
1311.47 Da
Amino Acids
10 AA
Evidence
Clinical
Regulatory Status
FDA-approved (Trelstar) for prostate cancer and precocious puberty. Not approved for HPTA restoration/PCT — this is an off-label research application.
In Plain English
A powerful hormone signal that can restart your body's testosterone-producing system after it has been shut down by external androgens. Think of it as pressing a hard reset button on your hypothalamus-pituitary-testes axis — one carefully timed injection triggers a large signal surge that can wake up the system after it went quiet.
Overview
Triptorelin is a synthetic analogue of gonadotropin-releasing hormone (GnRH/LHRH) with substitution of D-tryptophan at position 6, which significantly extends its potency and duration compared to native GnRH. FDA-approved for advanced prostate cancer (Trelstar) and precocious puberty. In the TRT/performance research community, a single injection protocol has been studied for HPTA (hypothalamic-pituitary-testicular axis) restoration following suppression from exogenous androgens, showing potential to restart endogenous testosterone production in a compressed timeframe versus traditional SERM-based PCT.
Common Formats
- Lyophilized powder (injectable)
- Depot microspheres (1-month, 3-month, 6-month)
- 100mcg/200mcg vials for research use
Storage Notes
Lyophilized: refrigerate at 2–8°C, protect from light. Reconstituted: use within 24 hours if unpreserved. Depot formulations are single-use prefilled syringes.
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Related Compounds
Gonadorelin
The endogenous hypothalamic hormone that regulates the HPG axis through pulsatile GnRH receptor signaling, used in fertility and hormonal research.
Kisspeptin
An endogenous neuropeptide and master regulator of the HPG axis, GnRH release, and reproductive function with significant clinical research interest.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.