Kisspeptin
Kisspeptin-10 · Kisspeptin-54 · Metastin
An endogenous neuropeptide and master regulator of the HPG axis, GnRH release, and reproductive function with significant clinical research interest.
Half-Life
~2-3 minutes (KP-10), longer KP-54
MW
KP-10: 1302.5 Da, KP-54: ~6.5 kDa
Amino Acids
N/A
Evidence
Moderate Evidence
Regulatory Status
Research compound. Clinical trials for reproductive medicine.
In Plain English
The master on-switch for the reproductive hormone axis. Kisspeptin is the gate-keeper — it tells the hypothalamus to release GnRH, which triggers LH/FSH, which triggers testosterone or estrogen. It integrates body fat, stress, and season into fertility decisions.
Overview
Kisspeptin is produced by kisspeptin neurons in the hypothalamus and acts as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It triggers GnRH (gonadotropin-releasing hormone) release, which drives LH and FSH secretion. Critical for puberty onset and reproductive function.
Common Formats
- Lyophilized powder (injectable)
- IV infusion (clinical)
Storage Notes
-20°C lyophilized.
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Related Compounds
PT-141
FDA-approved melanocortin receptor agonist for hypoactive sexual desire disorder in premenopausal women, with off-label research in men.
Gonadorelin
The endogenous hypothalamic hormone that regulates the HPG axis through pulsatile GnRH receptor signaling, used in fertility and hormonal research.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.