Sermorelin
GHRH (1-29) · GRF 1-29 NH2
A 29-amino acid truncated analogue of endogenous GHRH, FDA-approved for pediatric GHD and widely researched for anti-aging and body composition.
Half-Life
~10-20 minutes
MW
3357.9 Da
Amino Acids
29 AA
Evidence
High Evidence
Regulatory Status
FDA-approved (pediatric GHD), commonly compounded for adult research use. Off-label adult use common.
In Plain English
A shorter copy of the natural hormone your hypothalamus makes to trigger growth hormone release. Because it works through your own pituitary, it produces natural, rhythmic GH pulses rather than flooding your system artificially.
Overview
Sermorelin is a synthetic peptide analogue of the first 29 amino acids of growth hormone releasing hormone (GHRH). It was FDA-approved for treatment of GH deficiency in children and has been extensively studied for its anti-aging and body composition effects in adults.
Common Formats
- Lyophilized powder (injectable)
Storage Notes
Lyophilized: 2-8°C (stable at room temp for months). Reconstituted: 4°C, 3-4 weeks.
Looking for multi-compound protocols?
Browse educational protocol discussions that include Sermorelin.
Related Compounds
CJC-1295
A long-acting GHRH analogue with a Drug Affinity Complex that extends its half-life dramatically, allowing weekly dosing for sustained GH elevation.
Ipamorelin
A highly selective GH secretagogue and ghrelin receptor agonist known for clean GH release without significant cortisol or prolactin stimulation.
GHRP-2
A potent GH secretagogue with strong ghrelin receptor activity, producing significant GH pulses with some cortisol and prolactin elevation.
Tesamorelin
FDA-approved GHRH analogue specifically studied for visceral fat reduction in HIV-associated lipodystrophy, with broader anti-aging research interest.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.