Vasopressin
ADH · Arginine vasopressin · AVP
Endogenous nonapeptide that regulates water retention, blood pressure, and social/memory behavior via V1 and V2 receptors.
Half-Life
~10–20 minutes (IV); longer intranasal due to mucosal absorption
MW
N/A
Amino Acids
N/A
Evidence
Clinical
Regulatory Status
FDA-approved (septic shock, diabetes insipidus); intranasal research use
In Plain English
The "water conservation" hormone that tells your kidneys to hold onto water. Also consolidates memories and enhances social recognition in the brain. Used as an intranasal spray in memory and PTSD research.
Overview
Vasopressin (ADH, AVP) is a 9-amino acid peptide produced in the hypothalamus and released from the posterior pituitary. It has two primary functions: water homeostasis (via V2 receptors in the kidney collecting ducts) and cardiovascular/behavioral effects (via V1 receptors). Research interest spans cognitive enhancement, social bonding, PTSD treatment, and hemodynamic support. Intranasal vasopressin has shown acute memory and social cognition benefits in human studies.
Common Formats
- Intranasal spray
- Injectable (clinical)
Storage Notes
Refrigerate. Intranasal: protect from light.
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Related Compounds
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