Teriparatide
PTH (1-34) · Forteo · Forsteo
A recombinant fragment of human parathyroid hormone (PTH 1-34), FDA-approved for osteoporosis, and the only anabolic (bone-building) peptide therapy approved for clinical use.
Half-Life
~1 hour (subcutaneous)
MW
4117.7 Da
Amino Acids
34 AA
Evidence
High Evidence
Regulatory Status
FDA-approved (Forteo), EMA-approved (Forsteo). Approved for osteoporosis treatment up to 24 months lifetime. Prescription-only. A biosimilar (Bonsity, Tymlos comparison) is available. Maximum lifetime use limited due to osteosarcoma risk observed in rat studies (not confirmed in humans but precautionary).
In Plain English
A piece of the parathyroid hormone that actually builds new bone — unlike most osteoporosis drugs that just slow bone loss. Teriparatide tells your bone-building cells to work harder, making it the only prescription peptide that creates new bone tissue. Used to treat severe osteoporosis and studied for faster fracture healing.
Overview
Teriparatide is a synthetic 34-amino acid N-terminal fragment of human parathyroid hormone (hPTH 1-84). Unlike antiresorptive osteoporosis drugs (bisphosphonates, denosumab) that only slow bone loss, teriparatide actively stimulates new bone formation. FDA-approved since 2002 for postmenopausal osteoporosis, male osteoporosis, and glucocorticoid-induced osteoporosis. It significantly reduces vertebral fracture risk (65% reduction in clinical trials) and improves bone mineral density at spine and hip. Outside approved indications, it has been studied for fracture healing acceleration and stress fracture management in athletes. Intermittent pulsatile administration is key — continuous PTH infusion causes bone resorption, while once-daily injections produce net anabolic effects.
Common Formats
- Pre-filled pen injector (20 mcg/dose)
- Subcutaneous injection
Storage Notes
Refrigerate at 2-8°C. Do not freeze. In-use pen can be stored at room temperature for up to 28 days. Discard after 28 days of use. Protect from light.
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Related Compounds
IGF-1 LR3
A potent long-acting variant of IGF-1 with a 13-amino acid extension and substitution that dramatically extends its half-life and prevents protein binding.
IGF-1 DES
A truncated, highly potent form of IGF-1 lacking the first 3 amino acids, with extremely short half-life and strong local anabolic effects.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.