Snap-8
Acetyl Octapeptide-3 · Leuphasyl + Argireline combined concept · AO3
An extended octapeptide analogue of Argireline that adds additional SNARE complex inhibition domains, studied for greater potency in reducing expression-line wrinkles compared to Argireline alone.
Half-Life
N/A (topical cosmetic)
MW
1075.2 Da
Amino Acids
8 AA
Evidence
Moderate Evidence
Regulatory Status
Cosmetic ingredient. INCI: Acetyl Octapeptide-3. No therapeutic claims permitted.
In Plain English
Think of Argireline as a key that fits partially into a lock; Snap-8 is a longer, more complete key for the same lock. The "lock" is a protein complex your nerves use to release signals that cause muscles to contract — the better fit means greater muscle relaxation and smoother expression lines.
Overview
Snap-8 (Acetyl Octapeptide-3) is an extension of the Argireline (Acetyl Hexapeptide-3) sequence, adding two additional amino acids to the N-terminal portion of SNAP-25. This broader SNARE-inhibitory domain is reported to produce greater reduction in muscle contraction vs Argireline at equivalent concentrations. It is used in cosmetic formulations targeting forehead lines, crow's feet, and other expression-related wrinkles. Like Argireline, it is topically applied and does not produce systemic neuromuscular effects.
Common Formats
- Topical serum
- Eye cream
- Forehead treatment formulations
Storage Notes
Room temperature in opaque packaging. Stable across typical cosmetic formulation pH range.
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Related Compounds
Argireline
A synthetic acetyl hexapeptide that mimics the N-terminus of SNAP-25, inhibiting neuromuscular signalling to relax facial muscles and reduce expression-line wrinkles — widely used in cosmetic skincare.
Matrixyl
A palmitoylated pentapeptide and one of the most widely studied and used cosmetic anti-aging peptides, functioning as a matrikine to stimulate collagen and extracellular matrix production.
GHK-Cu
A naturally occurring copper complex peptide with potent wound healing, anti-aging, and regenerative properties studied extensively for skin and tissue applications.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.