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GLP-2

Glucagon-like peptide-2 · Teduglutide analog

Clinicalmetabolic

Intestinotrophic hormone that promotes gut epithelial growth, repair, and nutrient absorption — clinically used for short bowel syndrome.

Half-Life

~7 minutes (native); ~2–3 hours (DPP-IV resistant analogs)

N/A

Amino Acids

N/A

Evidence

Clinical

Regulatory Status

Analog (Teduglutide) FDA-approved for short bowel syndrome

In Plain English

A gut-specific growth factor secreted alongside GLP-1 after eating. Grows the lining of your intestine taller and improves nutrient absorption. An approved drug (Teduglutide/Gattex) for short bowel syndrome patients who need IV nutrition.

Overview

GLP-2 (Glucagon-like peptide-2) is a 33-amino acid peptide co-secreted with GLP-1 from intestinal L-cells in response to food. Unlike its sister peptide GLP-1, GLP-2 acts primarily as an intestinal growth factor rather than an appetite/glucose regulator. A degradation-resistant analog (Teduglutide/Gattex) is FDA-approved for short bowel syndrome. Researcher interest focuses on gut barrier enhancement, IBD, and nutrient optimization.

Common Formats

Injectable (subcutaneous)

Storage Notes

Refrigerate. Avoid repeated freeze-thaw cycles.

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Related Compounds

KPV

C-terminal tripeptide fragment of alpha-MSH with potent anti-inflammatory and gut-healing properties.

Larazotide Acetate

First-in-class tight junction peptide that reduces intestinal permeability (leaky gut) and zonulin-related inflammation.

BPC-157

A 15 amino acid peptide derived from human gastric juice, widely researched for its tissue-healing and cytoprotective properties.

Semaglutide

A GLP-1 receptor agonist with FDA approval for type 2 diabetes and obesity, demonstrating unprecedented weight loss results in clinical trials.

Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.