GHK (Glycine-Histidine-Lysine)
Copper-free GHK · GHK tripeptide · Gly-His-Lys
The copper-free parent tripeptide of GHK-Cu, studied independently for wound healing, gene expression modulation, and anti-inflammatory activity without requiring copper chelation.
Half-Life
Short (minutes systemically). Extended local activity topically.
MW
340.38 Da
Amino Acids
3 AA
Evidence
Moderate Evidence
Regulatory Status
Cosmetic ingredient in various forms. Research compound for injectable/systemic use.
In Plain English
A tiny three-amino-acid signal molecule your body makes naturally. Think of it as a "youth signal" — when your body detects GHK, it activates repair and regeneration programs. Levels drop as you age, which is why researchers are interested in supplementing it.
Overview
GHK (Gly-His-Lys) is the parent tripeptide naturally found in human plasma that forms the GHK-Cu complex when bound to copper. When studied without copper, GHK itself retains significant biological activity — activating wound healing pathways, modulating inflammatory gene expression, and signalling through growth factor receptors. Plasma concentrations decline with age (from ~200 ng/mL at age 20 to ~80 ng/mL at age 60), making it of interest to longevity researchers.
Common Formats
- Topical serum (copper-free)
- Lyophilized research powder
Storage Notes
Store in cool, dry conditions. Lyophilized: -20°C long term. Aqueous solutions: refrigerate and use promptly.
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Related Compounds
GHK-Cu
A naturally occurring copper complex peptide with potent wound healing, anti-aging, and regenerative properties studied extensively for skin and tissue applications.
BPC-157
A 15 amino acid peptide derived from human gastric juice, widely researched for its tissue-healing and cytoprotective properties.
Palmitoyl GHK (Pal-GHK)
Lipophilic derivative of GHK peptide with enhanced skin penetration — cornerstone of anti-aging skincare formulations.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.