Palmitoyl GHK (Pal-GHK)
Palmitoyl Tripeptide-1 · Pal-GHK-Cu
Lipophilic derivative of GHK peptide with enhanced skin penetration — cornerstone of anti-aging skincare formulations.
Half-Life
N/A (topical)
MW
N/A
Amino Acids
N/A
Evidence
Clinical
Regulatory Status
Cosmetic ingredient (INCI: Palmitoyl Tripeptide-1)
In Plain English
GHK peptide attached to a fatty acid tail so it can sink through skin layers. Without the fatty acid, GHK just sits on top of skin barely penetrating. The fatty acid acts as a molecular delivery vehicle into the dermis where collagen is made.
Overview
Palmitoyl GHK (Pal-GHK or Palmitoyl Tripeptide-1) is a fatty acid-conjugated form of GHK that dramatically improves skin penetration compared to the parent peptide. Often combined with copper (Pal-GHK-Cu) for enhanced activity. It stimulates collagen, elastin, and proteoglycan synthesis in dermal fibroblasts, reducing wrinkles and improving skin firmness. One of the most evidence-supported cosmetic peptides with over 20 years of commercial use.
Common Formats
- Topical cream/serum
- Injectable (research, off-label)
Storage Notes
Room temperature in opaque packaging. Stable in aqueous formulations with appropriate pH.
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Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.