Angiotensin (1-7)
Ang-(1-7) · Heptapeptide angiotensin
Endogenous heptapeptide that counterbalances Angiotensin II — cardioprotective, anti-fibrotic, and vasodilatory.
Half-Life
~30 minutes (native); longer with formulation
MW
N/A
Amino Acids
N/A
Evidence
Clinical
Regulatory Status
Clinical trials for COVID-19, lung fibrosis, metabolic syndrome
In Plain English
The "good" angiotensin — the natural counter-balance to the blood pressure-raising, tissue-scarring angiotensin II. Naturally made by ACE2 — the same enzyme SARS-CoV-2 hijacks, which is partly why COVID damages organs.
Overview
Angiotensin (1-7) is an endogenous heptapeptide produced from angiotensin II by the enzyme ACE2 — the same receptor involved in SARS-CoV-2 entry. It acts as a functional antagonist of Angiotensin II, opposing its vasoconstrictive, pro-fibrotic, and pro-inflammatory effects. The Mas receptor axis (Ang-(1-7)/ACE2/Mas) is a protective arm of the renin-angiotensin system. Research covers cardiovascular protection, metabolic benefits, lung injury, and COVID-19 sequelae.
Common Formats
- Injectable (intravenous in trials)
- Injectable (subcutaneous)
Storage Notes
Freeze at -20°C. Rapidly degraded at room temperature.
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Related Compounds
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.