NMN research guide: NAD+ precursor mechanism, bioavailability data, sublingual vs oral vs IV routes, dosing protocols, and stack context with sirtuins and longevity compounds.

Research guide to melatonin covering physiological vs pharmacological dosing, extended-release vs immediate-release forms, oncostatic properties, mitochondrial antioxidant role, SIRT1 activation, and combination with Epitalon for longevity research.

Comprehensive research guide to curcumin — covering NF-κB and COX-2 inhibition mechanisms, the bioavailability problem and solutions (BCM-95, Longvida, Meriva, piperine), dosing protocols, and anti-inflammatory research.

A research roundup covering major themes in peptide and longevity science for Q2 2026 — GLP-1 receptor agonist expansion, GH peptide research, senolytic compounds, NAD+ clinical data, AI-assisted peptide design, and the evolving regulatory landscape for research peptides.

Research overview of Epithalon (Epitalon) — the synthetic tetrapeptide Ala-Glu-Asp-Gly developed by Vladimir Khavinson. Covers telomerase activation mechanism, typical course protocols (10-20mg over 10-20 days), IV vs SubQ vs intranasal administration, cycling schedules, and published research findings.

Research overview of oxaloacetate (OAA) as a longevity and metabolic compound — its role as a Krebs cycle intermediate, NAD+ precursor effects, caloric restriction mimetic properties, AMPK activation, neuroprotection, and research on anhydrous oxaloacetate (benaGene) at 100-300mg/day.

Comprehensive anti-aging peptide stack design guide covering Epitalon telomere courses, GHK-Cu gene expression remodeling, SS-31 mitochondrial cardiolipin, MOTS-c metabolic aging, and Humanin cytoprotection — with sequencing strategies, budget tiers, and reconstitution for all five compounds.

Seasonal review of research stack developments — updated GLP-1 peptide data, GH secretagogue protocol refinements, nootropic stack updates, longevity compound rankings, what's new in research for spring 2026, and recommended starting stacks by goal.

Comprehensive research comparison of all NAD+ precursor pathways — NMN, NR, sublingual NMN, IV NAD+, and niacin — covering biosynthesis routes (Preiss-Handler, salvage, de novo pathways), bioavailability research, tissue distribution, and cost-per-dose analysis.

Comprehensive resveratrol research guide covering SIRT1 activation, trans vs cis isomers, bioavailability challenges, micronized and liposomal forms, 150-500mg dosing protocols, and the NMN+resveratrol combination rationale from longevity research.

A research-focused guide to telomere biology, telomerase activators (Epitalon, TA-65/cycloastragenol), lifestyle interventions, telomere measurement methods, and Epitalon dosing protocols.

Research comparison of the three mitochondrial-derived peptides — MOTS-c (AMPK activation), SS-31 (cardiolipin binding), and Humanin (cytoprotection/IGF-1) — with dosing protocols, combination rationale, and longevity vs performance applications.

Research overview of taurine — the conditionally essential amino acid that declines with age, with mitochondrial membrane function research, 2023 longevity aging study data, cardiovascular benefits, exercise performance, and 1-3g dosing protocols.

Research comparison of IV NAD+, NMN, NR, and sublingual routes — covering bioavailability, PARP enzyme substrate, sirtuin activation, mitochondrial biogenesis, IV flush effects, and typical clinical protocols from 500–1500mg.

Deep-dive into autophagy research: how fasting triggers cellular cleanup, the role of mTOR and AMPK signaling, peptide interactions, and protocol timing notes for researchers.

Research guide to SS-31 (Elamipretide) — the Szeto-Schiller mitochondria-targeting peptide that stabilizes cardiolipin in the inner mitochondrial membrane, with Phase 2/3 heart failure trial data, dosing, and longevity applications.

A research overview of four longevity-focused peptides — Epitalon, MOTS-c, SS-31, and Humanin — covering mechanisms, typical research doses, and how they may complement each other.

Research overview of spermidine — the polyamine longevity compound that induces autophagy independently of mTOR, with cardiovascular mortality data, dosing protocols, and wheat germ extract sourcing.

Complete research guide to fisetin as a senolytic agent — flavonoid mechanism, comparison with dasatinib/quercetin, 20 mg/kg pulsed research dosing, 500–1500 mg human protocols, 2-day pulse timing, bioavailability challenges, and liposomal fisetin.

The complete performance research framework: foundation supplements, GH peptide optimization, cognitive enhancement, sleep and recovery, and longevity protocols — with budget tiers.

A research-grounded comparison of NMN, resveratrol, and pterostilbene — mechanisms, dosing, bioavailability, evidence levels, and synergy arguments explained.

A research deep-dive into NAD+ precursors, senolytic compounds, and longevity peptides — including Epitalon, MOTS-c, SS-31, and thymosin alpha-1.

Epitalon and Epithalon are the same tetrapeptide. Naming disambiguation, telomerase activation research, dosing protocols, and longevity stack context clarified.

NMN vs NR vs nicotinic acid: bioavailability, dosing ranges, sirtuin research, and how to stack NAD+ precursors with longevity peptides.

Epitalon research overview: telomerase activation mechanism, pineal peptide background, typical research dosing context, and storage notes for this longevity compound.

Research overview of the four most-studied longevity peptides: Epitalon (telomerase), MOTS-c (mitochondrial metabolism), SS-31 (mitochondrial membrane), and Humanin (cytoprotection). Includes dosage tables and reconstitution math.