Ziconotide
Prialt · SNX-111 · Omega-conotoxin MVIIA
An FDA-approved synthetic analogue of a peptide toxin from the cone snail Conus magus, delivered intrathecally for severe chronic pain refractory to other treatments — the first approved conotoxin therapeutic.
Half-Life
~4.6 hours (intrathecal). Not detectable systemically at therapeutic intrathecal doses.
MW
2639 Da
Amino Acids
25 AA
Evidence
High Evidence
Regulatory Status
FDA-approved (Prialt, 2004) for severe chronic pain via intrathecal delivery. Prescription only. Schedule V controlled substance in the US despite non-opioid mechanism.
In Plain English
A peptide borrowed from cone snail venom — one of nature's most precise pain-blocking tools. The snail uses it to instantly paralyse prey; scientists modified it to selectively block the exact calcium channels that pain signals need to travel from nerve to nerve. Unlike opioids, your body never becomes tolerant to it and you won't become dependent on it.
Overview
Ziconotide (Prialt) is a 25-amino acid synthetic analogue of omega-conotoxin MVIIA, derived from the marine cone snail Conus magus. It is FDA-approved for the management of severe chronic pain in patients who are intolerant of, or refractory to, other treatments including systemic analgesics and intrathecal morphine. It is administered exclusively via intrathecal (spinal) infusion through an implanted pump system. Ziconotide cannot cross the blood-brain barrier when given systemically — the intrathecal route is mandatory. It is a non-opioid analgesic with no tolerance development or dependence potential, representing a unique mechanistic alternative to opioids for severe pain.
Common Formats
- Intrathecal infusion via implanted pump (only approved route)
- 25 mcg/mL and 100 mcg/mL intrathecal solutions
Storage Notes
Refrigerate (2-8°C). Do not freeze. Prialt is light-sensitive. Once in pump, stability per manufacturer guidelines (up to 60 days at 37°C in approved pumps).
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Related Compounds
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.