Pramlintide
Symlin · AC137 · Pramlintide acetate
An FDA-approved synthetic analogue of the pancreatic hormone amylin, used as an adjunct to insulin therapy in type 1 and type 2 diabetes, with research interest in weight management and satiety.
Half-Life
~48 minutes (subcutaneous)
MW
3949.4 Da
Amino Acids
37 AA
Evidence
High Evidence
Regulatory Status
FDA-approved (Symlin) for T1D and T2D as adjunct to insulin. Prescription required. Not approved standalone for weight loss.
In Plain English
Your pancreas makes two hormones when you eat — insulin and amylin. Most diabetes medications only replace insulin. Pramlintide replaces amylin, which tells your brain you're full, slows food digestion, and prevents your liver from dumping extra sugar after meals. It fills in the missing piece insulin alone can't address.
Overview
Pramlintide (brand name Symlin) is an FDA-approved synthetic analogue of the pancreatic hormone amylin, produced by beta cells alongside insulin. Amylin plays a key role in post-meal glucose control, suppressing glucagon, slowing gastric emptying, and reducing food intake via central satiety signalling. Pramlintide is approved as an adjunct to insulin in both T1D and T2D, and its weight-reducing side effect has generated research interest in obesity management, though it is not approved for weight loss alone.
Common Formats
- Pre-filled SQ pen (Symlin)
- Multi-dose vial (prescription)
Storage Notes
Refrigerate unopened vials (2-8°C). Opened vials: refrigerate or room temperature up to 28 days. Do not freeze.
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Related Compounds
Semaglutide
A GLP-1 receptor agonist with FDA approval for type 2 diabetes and obesity, demonstrating unprecedented weight loss results in clinical trials.
Liraglutide
A once-daily GLP-1 receptor agonist with FDA approval for T2D and obesity, the predecessor to semaglutide with strong clinical evidence.
Cagrilintide
A long-acting amylin analogue in Phase III clinical trials, studied for weight management and metabolic disease, often in combination with semaglutide (CagriSema) for synergistic weight reduction.
Educational Disclaimer: All information on this page is for educational and research purposes only. This does not constitute medical advice, diagnosis, or treatment recommendation. Consult a qualified healthcare professional.